Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.

Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood.Genomewide association neflintw-r6mpw studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has not been fully explored.In this study, we report the use of whole exome sequencing (WES) in seven densely-aff

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Effects of dietary intake of Colla corii asini on skin parameters and appearance: Results of a 12-week randomized, controlled, open-labeled trial

Background: As a traditional Chinese medicine, the Colla corii asini (CCA), obtained from the skin of Equus animus L, has been used to nourish blood in China for more than 2000 years.The beneficial role of CCA supplementation in beauty has been reported caruso milk thistle in different case studies; however, research supporting these claims remains

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Identification of Mutator-Derived Alternative Splicing Signatures of Genomic Instability for Improving the Clinical Outcome of Cholangiocarcinoma

BackgroundCholangiocarcinoma is an aggressive carcinoma with increasing incidence and poor outcomes worldwide.Genomic instability and alternative splicing (AS) events are hallmarks of carcinoma development and progression.The relationship between genomic instability, AS events, and tumor immune microenvironment remain unclear.MethodsThe splicing pr

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Tiempos de Guerra. El soldado que salvó Spielberg

Durante read more la Segunda Guerra Mundial, concretamente tras el Desembarco de Normandía, unos soldados norteamericanoscapitaneados por Jonh Miller deben arriesgar sus vidas para salvar al soldado James Ryan, cuyos tres hermanoshan muerto en la guerra.Lo único que se sabe del soldado Ryan es que se lanzó con su escuadrón de paracaidistasdetr�

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